Brainsight 2.5 is released for all users

We are happy to announce the release of Brainsight 2.5.

Before proceeding with this update, please read the following important information.

Minimum requirements:

  • macOS 10.13 High Sierra is now the minimum requirement, increased from macOS 10.11 El Capitan in Brainsight 2.4. For a free update, visit <>. Contact us if you need to upgrade your Mac hardware.
  • This version of Brainsight was tested against macOS 10.13.6 (High Sierra), 10.14.6 (Mojave), 10.15.7 (Catalina), 11.7.4 (Big Sur), 12.6.3 (Monterey), and 13.2 (Ventura).
  • Mac OS X 10.12 (Sierra) and earlier are unsupported.

Important Compatibility Note:

  • The project file format has changed. Brainsight 2.5 can open documents created by older versions of Brainsight, but older versions of Brainsight cannot open documents created by Brainsight 2.5.

Changes since version 2.4.11:

  • Brainsight can now simulate the induced electric field due to a TMS stimulation at a target location. It does this by interacting with SimNIBS, a third party software that must also be installed. The Targets window now allows associating a TMS coil model and stimulation strength with each target. The resulting simulation appears overlaid in 2D and 3D images, and can be customized from the Inspector window.
  • 3D reconstructions (like the skin reconstruction) are now coloured by blending any enabled overlays atop the reconstruction’s own colour.
  • Overlays now support time series data (though only from NIfTI and MINC2 files, not other formats). The Overlays window and Inspector window now have a new slider to choose the time offset.
  • Very large datasets (with more than 2^31 voxels) can now be used.
  • Made various accuracy improvements to Vet Robot stereo calibration and subject registration, resulting in more accurate targeting during surgery.
  • In the Session Perform window, creating new samples is now disallowed if the relevant Polaris tools are not visible.
  • In the Session Perform window, the ‘stream to file’ feature now includes EMG waveform data and the coordinate system for selected targets and created samples.
  • In the Session Perform window, the ‘Sample Now’ button is now disabled if the required tools are not visible to the Polaris camera.
  • When working with the Axilum robot/cobot, a new ‘scalp offset’ distance can be specified to keep the TMS coil a few millimetres above the scalp to account for the thickness of an EEG cap for example.
  • EMG waveform views now visually indicate when a waveform has exceeded the EMG pod device’s maximum range of 2.25 mV.
  • Added support for the Cornell University (Johnson, Philippa J; Barry, Erica F) canine atlas.
  • Fixed various bugs with some DICOM datasets, where images would appear split in half, have gaps, or have missing slices.
  • Fixed a longstanding bug where reconstructions based on ROIs would claim that re-computation was necessary, even though the ROI hadn’t changed. (This was partly fixed in 2.4, but still occurred for re-opened projects.)
  • ROIs can now be created by importing from a medical image file (DICOM, NIfTI, MINC, etc.).
  • Fixed a bug in the ROI window where the pencil and eraser tools would not work correctly at the edge of view, especially when moving the mouse quickly.
  • NIRS waveforms can be imported from a .nirs file, thus allowing importing data from other manufacturers’ NIRS devices.
  • Fixed a bug (introduced in Brainsight 2.4.11) where the SD.SrcPos and SD.SrcPos3D fields in exported .nirs files were swapped.
  • Fixed a bug (introduced in Brainsight 2.4.5) where the SD.SrcPos field in exported .nirs files were in decimetres instead of centimetres. (The SD.SrcPos3D field was exported correctly in millimetres though.)
  • Assembly Lists and Cap Layouts can now be created by importing from a .nirs file.
  • Calibrating a TMS coil or other tool now allows for the tool tracker and calibration tracker to move together (relative to the camera), instead of failing if either tool moved relative to the camera.
  • Polaris tool visibility status now uses a larger coloured area, making it more visible from father away.
  • The enabled/disabled state of Polaris tools in the Polaris Configuration window are now remembered across quit/relaunch.
  • Landmarks, targets, electrodes, and samples can now be clicked in 3D image views to select the corresponding item in the related table view.
  • Targets can now be exported to a text file from the Targets window (export was previously possible, but only from the Session Review window).
  • In the Targets window, if a reconstruction is chosen in the ‘optimize traj. to’ popup menu, clicking in 2D views no longer reorients crosshairs.
  • Exporting curvilinear reconstructions in the PLY format now includes the voxel values in greyscale, whereas previously no colour was exported, only the shape.
  • When exporting reconstructions as STL, VTK, and PLY you can now choose between the ASCII and binary variants of these file formats.
  • When importing a reconstruction from file, the object can now be placed relative to a chosen target (useful for placing chambers for example).
  • The crosshairs in 2D image views now have a small gap in the middle so as not to obscure the very thing being targeted.
  • Wherever 4×4 matrices can be imported from a file, a new file format is now supported namely plain text files with 16 numbers within.
  • The crosshairs offset slider now allows a large range.
  • When opening a project file, if there are referenced external files (datasets, CAD files) that can’t be found, the dialog that asks to find them now (by default) disables files with different names, thus making it much easier to find the correct file.
  • A new preference allows changing the colours of the bullseye views, especially useful for colour blind users.
  • A new preference allows changing the font size of the bullseye views.
  • A new preference allows specifying default EMG baseline and trial durations that will be used when creating new sessions.
  • Native support for Apple Silicon processors.
  • Improved support for macOS 11 Big Sur, macOS 12 Monterey, and macOS 13 Ventura.
  • Various performance improvements:
    • Exporting DXF files is now much faster, especially for large reconstructions.
    • Updating an atlas space template overlay is now much faster.
    • Reorienting the anatomical dataset is now much faster.
    • Creating curvilinear reconstructions is now much faster.
    • Creating skin and other surface reconstructions is faster.
  • Fixed miscellaneous bugs.


  • Brainsight 2.5 can be downloaded from our website here: <>
  • You might also need to download the latest “Support Files Human” and/or “Support Files Vet” if you have an older version. Brainsight will warn at launch if that’s the case.
  • You’ll need your serial number, which you can get from Brainsight itself from the Brainsight menu > ‘Enter/View Serial Number’.


  • Please report any and all bugs, feedback, suggestions, etc. to <> or by phone at +1-866-984-3888 (Canada & USA) or +1-514-284-3888.

Thank you,

The Rogue Research Team